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It is advisable to initiate treatment with an immediate-release (IR) form of morphine before using a prolonged-release (LP) form of morphine.
Administration mode
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With prolonged-release forms, the total daily dose should be divided into two doses, usually equivalent, 12 hours apart.
In the event that the capsules cannot be swallowed, their contents can be administered directly in a semi-solid food (puree, jam, yogurt), or in gastric or gastrostomy tubes with a diameter greater than 16 FG with an open distal end. or with side pores. Rinsing the probe with 30 to 50 ml of water is sufficient.
Drugs interactions.
It should be taken into account that many drugs or substances can add up their depressant effects on the central nervous system and contribute to reducing vigilance. These are morphine derivatives (analgesics, cough suppressants and substitution treatments), neuroleptics, barbiturates, benzodiazepines, anxiolytics other than benzodiazepines (for example meprobamate), hypnotics, sedative antidepressants (amitriptyline, doxepine, mianserin, mirtazapine, trimipramine), sedating H1 antihistamines, central antihypertensive drugs, baclofen and thalidomide.
Possible side effects.
Drowsiness
Confusion
Nausea
Vomiting
Constipation
Sedation
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